![]() Yates had developed a sophisticated technology that combines liquid chromatography, mass spectrometry, and bioinformatics to identify the hundreds of proteins involved in complex cellular mechanisms from small samples of biological material. The study began when Diana Chu, a postdoctoral fellow in Meyer's lab who is now an assistant professor at San Francisco State University, decided to take advantage of a collaboration that Meyer had established with John Yates at the Scripps Research Institute in La Jolla, California. “Sperm look very different between a worm and a human,” she said, “but the actual processes that allow the packing and tight structure of DNA in the sperm head are very similar.” ![]() elegans to learn more about the molecular mechanisms that may cause such cases of infertility in humans. Meyer and her colleagues decided to investigate the formation of sperm in C. The sperm cells of infertile males often contain DNA that is fragmented or not as tightly packed as normal sperm. Nearly one in six human couples suffers from infertility, and defects in a male's sperm are partly or wholly responsible in about half of these cases. Many of the genes that we have identified map to the parts of chromosomes that human genetics researchers have identified as important for fertility. ![]()
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